Key takeaways
- Both are second-generation antihistamines, but they are different active ingredients.
- Product labeling, other medicines, health history, age, and side-effect experience can affect the choice.
- Follow the specific product label and ask a clinician or pharmacist when symptoms are persistent or the choice is unclear.
How they compare
EDITORIAL GUIDETopicCetirizinecetirizine hydrochlorideLoratadineloratadine
Medication familySecond-generation antihistamineSecond-generation antihistamine
Common discussionSeasonal or indoor allergy symptoms and hivesSeasonal or indoor allergy symptoms
Product formTablets, chewables, and oral solutionsTablets, chewables, and oral solutions
AccessCommonly available without a prescriptionCommonly available without a prescription
DecisionUse the product label and individual guidanceUse the product label and individual guidance
Primary sources
Labeling can change. Use the current FDA prescribing information and speak with a licensed clinician or pharmacist before making a treatment decision.