Key takeaways
- Wegovy contains semaglutide; Zepbound contains tirzepatide.
- They work through related but different incretin pathways and are not interchangeable products.
- The appropriate choice depends on approved indications, medical history, current medicines, risks, access, and personal treatment goals.
How they compare
EDITORIAL GUIDETopicWegovysemaglutideZepboundtirzepatide
Active ingredientSemaglutideTirzepatide
Medication classGLP-1 receptor agonistGIP/GLP-1 receptor agonist
Common FDA-approved focusChronic weight management for eligible patientsChronic weight management for eligible patients
AccessPrescription requiredPrescription required
DecisionRequires an individual clinician reviewRequires an individual clinician review
Primary sources
Labeling can change. Use the current FDA prescribing information and speak with a licensed clinician or pharmacist before making a treatment decision.